Biobehavioral mechanisms underlying testosterone and mood relationships in peripubertal female adolescents.

ABSTRACT: The pubertal transition is characterized by pronounced sex hormone fluctuation, refinement of affective neural circuitry, and an increased risk of depression in female adolescents. Sex hormones, including testosterone, exert modulatory effects on frontal-limbic brain networks and are associated with emotion dysregulation and depressive symptoms. Weekly changes in hormones predict affective symptoms in peripubertal female adolescents, particularly in the context of stress; however, the biobehavioral mechanisms underlying hormone change and mood relationships during the pubertal transition have yet to be determined and was the objective of the present study. Forty-three peripubertal female adolescents (ages 11-14) collected 8-weekly salivary hormone (estrone, testosterone) samples and mood a

SUBMITTER: Andersen E 

PROVIDER: S-EPMC10834847 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature