Sex, Ethnicity, Body Mass Index, and Environmental Exposures Associated With NSAID-Exacerbated Respiratory Disease Symptom Sequence.

ABSTRACT:

Background

Nonsteroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (N-ERD) has a triad of symptoms: nasal polyposis, asthma, and NSAID hypersensitivity. Little is known about symptom timing and disease progression.

Objective

The aim of this study is to characterize disease progression in N-ERD.

Methods

Patients with N-ERD were prospectively interviewed and classified into 4 groups based on their first symptom at initial N-ERD onset (asthma, nasal polyps, NSAID hypersensitivity, or all concurrently). Associations of patient characteristics with the 4 groups were examined, along with associations within the "asthma first" group.

Results

Patients (N = 240) were mostly female (68%) and self-identified as non-White (77%). Half (N = 119) reported

SUBMITTER: Dages KN 

PROVIDER: S-EPMC10834851 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature