Effect of a retinoic acid analogue on BMP-driven pluripotent stem cell chondrogenesis.

ABSTRACT: Osteoarthritis is the most common degenerative joint condition, leading to articular cartilage (AC) degradation, chronic pain and immobility. The lack of appropriate therapies that provide tissue restoration combined with the limited lifespan of joint-replacement implants indicate the need for alternative AC regeneration strategies. Differentiation of human pluripotent stem cells (hPSCs) into AC progenitors may provide a long-term regenerative solution but is still limited due to the continued reliance upon growth factors to recapitulate developmental signalling processes. Recently, TTNPB, a small molecule activator of retinoic acid receptors (RARs), has been shown to be sufficient to guide mesodermal specification and early chondrogenesis of hPSCs. Here, we modified our previous different

SUBMITTER: Mancini FE 

PROVIDER: S-EPMC10834951 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature