Distribution of multi-level B cell subsets in thymoma and thymoma-associated myasthenia gravis.

ABSTRACT: B-cell subsets in peripheral blood (PB) and tumor microenvironment (TME) were evaluated to determine myasthenia gravis (MG) severity in patients with thymoma-associated MG (TMG) and the distribution of B cells in type B TMG. The distribution of mature B cells, including Bm1-Bm5, CD19⁺ and CD20⁺ B cells and non-switched (NSMBCs) and switched (SMBCs) memory B cells, were determined in 79 patients with thymoma or TMG. Quantitative relationships between the T and TMG groups and the TMG-low and TMG-high subgroups were determined. NSMBCs and SMBCs were compared in TME and PB. Type B thymoma was more likely to develop into MG, with types B2 and B3 being especially associated with MG worsening. The percentage of CD19⁺ B cells in PB gradually increased, whereas the

SUBMITTER: Zhang P 

PROVIDER: S-EPMC10834956 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature