The J shaped association of age at menarche and cardiovascular events: systematic review and meta-analysis.

ABSTRACT: This study aimed to evaluate the association between age at menarche and cardiovascular (CV) events through a systematic review and meta-analysis of observational studies. A comprehensive literature search covering studies published from January 1, 2000, to October 31, 2023, was conducted in PubMed, MEDLINE, Embase, and Scopus. Twenty-nine observational studies involving 4,931,160 adult women aged 18 years or older were included. The meta-analysis revealed a J-shaped association between age at menarche and CV events. Individuals with menarche at 12-13 years exhibited the lowest risk, while those with younger (≤ 11 years) or older ages (14-15 years and ≥ 16 years) showed an increased risk. Notably, individuals with age at menarche of 16 years and older had the highest risk of CV events. The

SUBMITTER: Behboudi-Gandevan S 

PROVIDER: S-EPMC10834967 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature