Nanotexture and crystal phase regulation for synergistic enhancement in re-endothelialization on medical pure titanium surface.

ABSTRACT: Re-endothelialization has been recognized as a promising strategy to address the tissue hyperplasia and subsequent restenosis which are major complications associated with vascular implant/interventional titanium devices. However, the uncontrollable over-proliferation of smooth muscle cells (SMCs) limits the clinical application of numerous modified strategies. Herein, a novel modified strategy involving with a two-step anodic oxidation and annealing treatment was proposed to achieve rapid re-endothelialization function regulated by regular honeycomb nanotexture and specific anatase phase on the titanium surface. Theoretical calculation revealed that the presence of nanotexture reduced the polar component of surface energy, while the generation of anatase significantly enhanced the polar c

SUBMITTER: Zhang J 

PROVIDER: S-EPMC10835003 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature