Network architecture of intrinsic connectivity in a mammalian spinal cord (the central nervous system's caudal sector).

ABSTRACT: The vertebrate spinal cord (SP) is the long, thin extension of the brain forming the central nervous system's caudal sector. Functionally, the SP directly mediates motor and somatic sensory interactions with most parts of the body except the face, and it is the preferred model for analyzing relatively simple reflex behaviors. Here, we analyze the organization of axonal connections between the 50 gray matter regions forming the bilaterally symmetric rat SP. The assembled dataset suggests that there are about 385 of a possible 2,450 connections between the 50 regions for a connection density of 15.7%. Multiresolution consensus cluster analysis reveals a hierarchy of structure-function subsystems in this neural network, with 4 subsystems at the top level and 12 at the bottom-level. The top-le

SUBMITTER: Swanson LW 

PROVIDER: S-EPMC10835027 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature