An architecturally rational hemostat for rapid stopping of massive bleeding on anticoagulation therapy.

ABSTRACT: Hemostatic devices are critical for managing emergent severe bleeding. With the increased use of anticoagulant therapy, there is a need for next-generation hemostats. We rationalized that a hemostat with an architecture designed to increase contact with blood, and engineered from a material that activates a distinct and undrugged coagulation pathway can address the emerging need. Inspired by lung alveolar architecture, here, we describe the engineering of a next-generation single-phase chitosan hemostat with a tortuous spherical microporous design that enables rapid blood absorption and concentrated platelets and fibrin microthrombi in localized regions, a phenomenon less observed with other classical hemostats without structural optimization. The interaction between blood components and t

SUBMITTER: Lee VK 

PROVIDER: S-EPMC10835033 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature