Dataset Information
Extracellular matrix is the main targeted environment in early stage of pancreatic ductal adenocarcinoma.
Ontology highlight
ABSTRACT: Aim
Due to weak diagnosis and treatment of pancreatic ductal adenocarcinoma (PDAC), detection of PDAC possible biomarkers in early stage is the main aim of this study.Background
PDAC is known as an exocrine cancer with a 5-year overall survival of 11%.Methods
Gene expression profiles of early stage of PDAC tissue and normal tissue are downloaded from gene expression omnibus (GEO) and evaluated via GEO2R. The significant differentially expressed genes (DEGs) are investigated via protein-protein interaction (PPI) network analysis and gene ontology.Results
Among 104 DEGs, ALB, COL1A1, COL1A2, MMP1, POSTN, PLAU, and COL3A1 were pointed out as hub nodes. "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13" group of 52 biological terms were identified as the main affected terms.Conclusion
In conclusion, ALB, MMP1, and COL1A1 genes were highlighted as possible biomarkers of early stage of PDAC. Dysfunction of extracellular matrix was identified as a main event in patients.
SUBMITTER: Mansouri V
PROVIDER: S-EPMC10835096 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Publications
Extracellular matrix is the main targeted environment in early stage of pancreatic ductal adenocarcinoma.
Gastroenterology and hepatology from bed to bench 20230101 4
<h4>Aim</h4>Due to weak diagnosis and treatment of pancreatic ductal adenocarcinoma (PDAC), detection of PDAC possible biomarkers in early stage is the main aim of this study.<h4>Background</h4>PDAC is known as an exocrine cancer with a 5-year overall survival of 11%.<h4>Methods</h4>Gene expression profiles of early stage of PDAC tissue and normal tissue are downloaded from gene expression omnibus (GEO) and evaluated via GEO2R. The significant differentially expressed genes (DEGs) are investigat ...[more]