Extracellular matrix is the main targeted environment in early stage of pancreatic ductal adenocarcinoma.

ABSTRACT:

Aim

Due to weak diagnosis and treatment of pancreatic ductal adenocarcinoma (PDAC), detection of PDAC possible biomarkers in early stage is the main aim of this study.

Background

PDAC is known as an exocrine cancer with a 5-year overall survival of 11%.

Methods

Gene expression profiles of early stage of PDAC tissue and normal tissue are downloaded from gene expression omnibus (GEO) and evaluated via GEO2R. The significant differentially expressed genes (DEGs) are investigated via protein-protein interaction (PPI) network analysis and gene ontology.

Results

Among 104 DEGs, ALB, COL1A1, COL1A2, MMP1, POSTN, PLAU, and COL3A1 were pointed out as hub nodes. "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13" group of 52 biological terms were identified as the main

SUBMITTER: Mansouri V 

PROVIDER: S-EPMC10835096 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature