Ongoing production of tissue-resident macrophages from hematopoietic stem cells in healthy adult macaques.

ABSTRACT:

Abstract

Macrophages orchestrate tissue immunity from the initiation and resolution of antimicrobial immune responses to the repair of damaged tissue. Murine studies demonstrate that tissue-resident macrophages are a heterogenous mixture of yolk sac-derived cells that populate the tissue before birth, and bone marrow-derived replacements recruited in adult tissues at steady-state and in increased numbers in response to tissue damage or infection. How this translates to species that are constantly under immunologic challenge, such as humans, is unknown. To understand the ontogeny and longevity of tissue-resident macrophages in nonhuman primates (NHPs), we use a model of autologous hematopoietic stem progenitor cell (HSPC) transplantation with HSPCs genetically modified to be marked

SUBMITTER: Rahmberg AR 

PROVIDER: S-EPMC10835270 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature