Dataset Information

Antibiotic and antifungal use in paediatric departments at three academic hospitals in South Africa.

ABSTRACT:

Objectives

South Africa implemented a National Strategic Framework to optimise antimicrobial stewardship in 2014; however, there is limited data on how this has affected prescribing, especially to children treated in academic centres.

Methods

We conducted a point prevalence survey using the World Health Organization (WHO) methodology to evaluate antibiotic and antifungal prescribing practices in paediatric departments at three academic hospitals in South Africa.

Results

We recorded 1946 antimicrobial prescriptions in 1191 children, with 55.2% and 39.2% of the antibiotics classified as WHO AWaRe Access and Watch drugs, respectively. There were significant differences in prescription of Reserve antibiotics and antifungals between institutions. Receipt of WHO Watch and Reserve antibiotics was independently associated with infancy (<12 months) and adolescents (13-17 years) (adjusted relative risk [aRR]: 2.09-9.95); prolonged hospitalisation (aRR: 3.29-30.08); rapidly or ultimately fatal illness (aRR: 1.94 to 5.52); and blood transfusion (aRR: 3.28-5.70). Antifungal prescribing was associated with treatment of hospital-associated infection (aRR: 2.90), medical prophylaxis (aRR: 3.30), and treatment in intensive care units (aRR: 2.15-2.27).

Conclusions

Guidance on optimisation of infection prevention and control practice and strengthening of antimicrobial stewardship would impact positively on the care of sick children in our setting.

SUBMITTER: Moore DP

PROVIDER: S-EPMC10835277 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature

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Publications

Antibiotic and antifungal use in paediatric departments at three academic hospitals in South Africa.

Moore David P DP Chetty Terusha T Pillay Ashendri A Karsas Maria M Cloete Jeané J Balakrishna Yusentha Y Reddy Tarylee T Archary Moherndran M van Kwawegen Alison A Thomas Reenu R Nakwa Firdose L FL Waggie Zainab Z Magrath Stephanie S Goga Ameena A Jeena Prakash P

IJID regions 20231220

<h4>Objectives</h4>South Africa implemented a National Strategic Framework to optimise antimicrobial stewardship in 2014; however, there is limited data on how this has affected prescribing, especially to children treated in academic centres.<h4>Methods</h4>We conducted a point prevalence survey using the World Health Organization (WHO) methodology to evaluate antibiotic and antifungal prescribing practices in paediatric departments at three academic hospitals in South Africa.<h4>Results</h4>We ...[more]

PMID: 38314394

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Dataset Information

Antibiotic and antifungal use in paediatric departments at three academic hospitals in South Africa.

Objectives

Methods

Results

Conclusions

Publications

Antibiotic and antifungal use in paediatric departments at three academic hospitals in South Africa.

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