Coupling allows robust mammalian redox circadian rhythms despite heterogeneity and noise.

ABSTRACT: Circadian clocks are endogenous oscillators present in almost all cells that drive daily rhythms in physiology and behavior. There are two mechanisms that have been proposed to explain how circadian rhythms are generated in mammalian cells: through a transcription-translation feedback loop (TTFL) and based on oxidation/reduction reactions, both of which are intrinsically stochastic and heterogeneous at the single cell level. In order to explore the emerging properties of stochastic and heterogeneous redox oscillators, we simplify a recently developed kinetic model of redox oscillations to an amplitude-phase oscillator with 'twist' (period-amplitude correlation) and subject to Gaussian noise. We show that noise and heterogeneity alone lead to fast desynchronization, and that coupling betwee

SUBMITTER: Del Olmo M 

PROVIDER: S-EPMC10835301 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature