Risk factors for childhood brain tumours: A systematic review and meta-analysis of observational studies from 1976 to 2022.

ABSTRACT:

Background

Childhood brain tumours (CBTs) are the leading cause of cancer death in children under the age of 20 years globally. Though the aetiology of CBT remains poorly understood, it is thought to be multifactorial. We aimed to synthesize potential risk factors for CBT to inform primary prevention.

Methods

We conducted a systematic review and meta-analysis of epidemiological studies indexed in the PubMed, Web of Science, and Embase databases from the start of those resources through 27 July 2023. We included data from case-control or cohort studies that reported effect estimates for each risk factor around the time of conception, during pregnancy and/or during post-natal period. Random effects meta-analysis was used to estimate summary effect sizes (ES) and 95% confidence

SUBMITTER: Onyije FM 

PROVIDER: S-EPMC10835339 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature