Anti-inflammatory response-based risk assessment in acute type A aortic dissection: A national multicenter cohort study.

ABSTRACT:

Background

Early identification of patients at high risk of operative mortality is important for acute type A aortic dissection (TAAD). We aimed to investigate whether patients with distinct risk stratifications respond differently to anti-inflammatory pharmacotherapy.

Methods

From 13 cardiovascular hospitals, 3110 surgically repaired TAAD patients were randomly divided into a training set (70%) and a test set (30%) to develop and validate a risk model to predict operative mortality using extreme gradient boosting. Performance was measured by the area under the receiver operating characteristic curve (AUC). Subgroup analyses were performed by risk stratifications (low versus middle-high risk) and anti-inflammatory pharmacotherapy (absence versus presence of ulinastatin use).

SUBMITTER: Liu H 

PROVIDER: S-EPMC10835346 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature