OSTEO18, a novel urinary proteomic signature, associated with osteoporosis in heart transplant recipients.

ABSTRACT:

Background

Immunosuppressive treatment in heart transplant (HTx) recipient causes osteoporosis. The urinary proteomic profile (UPP) includes peptide fragments derived from the bone extracellular matrix. Study aims were to develop and validate a multidimensional UPP biomarker for osteoporosis in HTx patients from single sequenced urinary peptides identifying the parent proteins.

Methods

A single-center HTx cohort was analyzed. Urine samples were measured by capillary electrophoresis coupled with mass spectrometry. Cases with osteoporosis and matching controls were randomly selected from all available 389 patients. In derivation case-control dataset, 1576 sequenced peptides detectable in ≥30 % of patients. Applying statistical analysis on these, an 18-peptide multidimensional

SUBMITTER: Yu YL 

PROVIDER: S-EPMC10835361 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature