Circulating microRNA expression and nonalcoholic fatty liver disease in adolescents with severe obesity.

ABSTRACT:

Background

Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases in children and adolescents. NAFLD ranges in severity from isolated hepatic steatosis to nonalcoholic steatohepatitis (NASH), wherein hepatocellular inflammation and/or fibrosis coexist with steatosis. Circulating microRNA (miRNA) levels have been suggested to be altered in NAFLD, but the extent to which miRNA are related to NAFLD features remains unknown. This analysis tested the hypothesis that plasma miRNAs are significantly associated with histological features of NAFLD in adolescents.

Aim

To investigate the relationship between plasma miRNA expression and NAFLD features among adolescents with NAFLD.

Methods

This study included 81 adolescents diagnosed with NAFLD a

SUBMITTER: Li YJ 

PROVIDER: S-EPMC10835537 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature