Association of urine autoantibodies with disease activity in systemic lupus erythematosus.

ABSTRACT:

Objective

The presence of urinary autoantibodies in patients with systemic lupus erythematosus (SLE) has been confirmed by several studies; however, the significance of their presence in urine remains unclear. This study aims to further investigate the association between urine autoantibodies and disease activity as well as organ involvement in SLE.

Methods

This cross-sectional study included 89 SLE patients. Data collected included anti-nuclear antibody (ANA), anti-ENA antibodies, and anti-dsDNA antibody levels in both serum and urine, complement (C) 3, C4 levels in serum, SLE disease activity index-2000 (SLEDAI-2000), renal domains of SLEDAI (RSLEDAI) and non-renal SLEDAI (NRSLEDAI).

Results

The rate of positive urine ANA (uANA) was 33.3% (29/87) among the enrolled

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10835792 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature