Efficacy and safety of stem cell therapy for Crohn's disease: a meta-analysis of randomized controlled trials.

ABSTRACT:

Purpose

Small-scale clinical trials have provided evidence suggesting the effectiveness of stem-cell therapy (SCT) for patients diagnosed with Crohn's disease (CD). The objective of the research was to systematically assess the effectiveness and safety of SCT for individuals diagnosed with CD through a comprehensive review and meta-analysis.

Methods

A search was conducted in Medline (PubMed), CENTER (Cochrane Library), and Embase (Ovid) to find randomized controlled trials (RCTs) that assessed the impact of SCT on the occurrence of clinical remission (CR) and severe adverse events (SAE) among patients diagnosed with CD. The Cochrane Q test and estimation of I² were used to assess heterogeneity among studies. After incorporating heterogeneity, a random-effects mode

SUBMITTER: Qiu Y 

PROVIDER: S-EPMC10835827 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature