Identification of DNA methylation biomarkers for evaluating cardiovascular disease risk from epigenome profiles altered by low-dose ionizing radiation.

ABSTRACT:

Background

Environmental exposure, medical diagnostic and therapeutic applications, and industrial utilization of radionuclides have prompted a growing focus on the risks associated with low-dose radiation (< 100 mGy). Current evidence suggests that such radiation can induce epigenetic changes. Nevertheless, whether exposure to low-dose radiation can disrupt endothelial cell function at the molecular level is unclear. Because endothelial cells play crucial roles in cardiovascular health and disease, we aimed to investigate whether low-dose radiation could lead to differential DNA methylation patterns at the genomic level in endothelial cell (EC) lines.

Methods

We screened for changes in DNA methylation patterns in primary human aortic (HAECs) and coronary artery endothelial

SUBMITTER: Park J 

PROVIDER: S-EPMC10835887 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature