T-type voltage-gated channels, Na⁺/Ca²⁺-exchanger, and calpain-2 promote photoreceptor cell death in inherited retinal degeneration.

ABSTRACT: Inherited retinal degenerations (IRDs) are a group of untreatable and commonly blinding diseases characterized by progressive photoreceptor loss. IRD pathology has been linked to an excessive activation of cyclic nucleotide-gated channels (CNGC) leading to Na⁺- and Ca²⁺-influx, subsequent activation of voltage-gated Ca²⁺-channels (VGCC), and further Ca²⁺ influx. However, a connection between excessive Ca²⁺ influx and photoreceptor loss has yet to be proven.Here, we used whole-retina and single-cell RNA-sequencing to compare gene expression between the rd1 mouse model for IRD and wild-type (wt) mice. Differentially expressed genes indicated links to several Ca²⁺-signalling related pathways. To explore these, rd1 and wt organo

SUBMITTER: Yan J 

PROVIDER: S-EPMC10836022 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature