The medial entorhinal cortex encodes multisensory spatial information.

ABSTRACT: Animals employ spatial information in multisensory modalities to navigate their natural environments. However, it is unclear whether the brain encodes such information in separate cognitive maps or integrates all into a single, universal map. We addressed this question in the microcircuit of the medial entorhinal cortex (MEC), a cognitive map of space. Using cellular-resolution calcium imaging, we examined the MEC of mice navigating virtual reality tracks, where visual and auditory cues provided comparable spatial information. We uncovered two cell types: "unimodality cells" and "multimodality cells". The unimodality cells specifically represent either auditory or visual spatial information. They are anatomically intermingled and maintain sensory preferences across multiple tracks and beha

SUBMITTER: Nguyen D 

PROVIDER: S-EPMC10836072 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature