Efficacy and tolerability of perampanel: a Chinese real-world observational study in epilepsy.

ABSTRACT:

Purpose

To investigate whether there exists a statistically significant distinction between the effectiveness and tolerance of perampanel (PER) and the number of antiseizure medications (ASMs) that were tried prior to administering PER.

Method

A prospective, observational study was performed at West China Hospital of Sichuan University. The study included patients diagnosed with epilepsy who were prescribed PER and were monitored for a minimum of 6 months. The efficacy of PER was evaluated at 1, 3, 6, and 12-month intervals by examining the retention rate and the 50% response rate. All statistical analyses were conducted using IBM SPSS Statistics version 25 (IBM Corporation, Armonk, New York).

Results

A total of 1,025 patients were identified, of which 836 were includ

SUBMITTER: Zeng Y 

PROVIDER: S-EPMC10836157 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature