Modular Titratable Polypills for Personalized Medicine and Simplification of Complex Medication Regimens.

ABSTRACT: Simplification of complex medication regimens in polypharmacy positively contributes to treatment adherence and cost-effective improved health outcomes. Even though fixed dose combination (FDC) drug products are the only currently available single dose poly-pill regimens, the lack of flexibility in dose adjustment of a single drug in the combination limits their efficacy. To fill the existing gap in drug dose personalization and simplification of complex medication regimens commonly encountered in the treatment of cardiovascular disease, tuberculosis, and tapering of corticosteroid therapy, a modular titratable polypill approach that simultaneously addresses both aspects is proposed. The polypill consists of modular units that contain different drugs at incremental or decremental doses to

SUBMITTER: Karavasili C 

PROVIDER: S-EPMC10836191 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature