Association between interleukin-6 and preterm birth: a meta-analysis.

ABSTRACT:

Background

Interleukin (IL)-6 is a pro-inflammatory cytokine that plays an important role in preterm birth (PTB), Several meta-analyses investigated the association between IL-6 and PTB, but definitive conclusion has not yet been achieved. This updated meta-analysis aimed to ascertain the association between IL-6 and PTB by examining IL-6 levels in both normal birth and PTB groups.

Material and methods

Prospective cohort studies were retrieved in PubMed, Embase, and the Cochrane library from their inception until 18 February 2020. The primary outcome was the association between IL-6 and PTB, and secondary outcomes were the association between IL-6 and spontaneous PTB.

Results

Nine studies involving 1904 patients were included. Overall, IL-6 from different sample types

SUBMITTER: Chang Y 

PROVIDER: S-EPMC10836263 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature