Evaluation of the Geographical Accessibility of Genome-Matched Clinical Trials on a National Experience.

ABSTRACT:

Background

Molecular-driven oncology allows oncologists to identify treatments that match a cancer's genomic profile. Clinical trials are promoted as an effective modality to deliver a molecularly matched treatment. We explore the role of geographical accessibility in Italy, and its impact on patient access to clinical trials.

Material and methods

We retrospectively reviewed molecular data from a single-institutional case series of patients receiving next-generation sequencing testing between March 2019 and July 2020. Actionable alterations were defined as the ones with at least one matched treatment on Clinicaltrials.gov at the time of genomic report signature. We then calculated the hypothetical distance to travel to reach the nearest assigned clinical trial.

Results

SUBMITTER: Crimini E 

PROVIDER: S-EPMC10836319 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature