Comparative efficacy and safety of anti-infective drugs for patients with mild to severe COVID-19: A systematic review and network meta-analysis of randomized controlled trials.

ABSTRACT:

Background

Different anti-infective drugs have been proposed for the treatment of patients with COVID-19. We carried out a network meta-analysis to assess their relative efficacy and safety.

Methods

We searched relevant databases for all randomized controlled trials that reported the efficacy and or safety of any anti-infective drugs published up to April 30, 2022 for different outcomes. We did both pairwise and network meta-analysis with 95% confidence intervals using a fixed-effect model. We assessed studies for quality of evidence using an extension of the standard Grading of Recommendations, Assessment, Development and Evaluation approach considering P<0.05 to be statistically significant.

Results

We included 68 RCTs for 27,680 participants on 22 anti-infective dr

SUBMITTER: Debela DT 

PROVIDER: S-EPMC10836338 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature