Dataset Information

Increased vascular inflammation on PET/CT in psoriatic arthritis patients in comparison with controls.

ABSTRACT:

Background

Patients with psoriatic arthritis (PsA) have an increased risk of cardiovascular disease, possibly due to a chronic inflammatory state.

Objectives

The main objective of this study was to investigate the difference in vascular inflammation, measured with 18-fluorodeoxyglucose positron emission tomography/CT (PET/CT), in PsA patients and controls. We conducted a secondary analysis to assess the association between clinical parameters of disease activity with vascular inflammation in PsA.

Methods

We included a total of 75 PsA patients with active peripheral arthritis (defined as ≥2 tender and swollen joints) from an ongoing clinical trial (EudraCT 2017-003900-28) and a retrospective group of 40 controls diagnosed with melanoma, without distant metastases and not receiving immunotherapy. The main outcome measure was aortic vascular inflammation which was measured on PET/CT scans using target-to-background ratios. Clinical disease activity in PsA was assessed with joint counts, body surface area and the Disease Activity index for PsA. Laboratory assessments included C reactive protein and erythrocyte sedimentation rate.

Results

Vascular inflammation was increased in patients with PsA in comparison with controls (mean target-to-background ratio for entire aorta, respectively, 1.63±0.17 vs 1.49±0.16; p=<0.001). This association remained significant after correction for gender, age, body mass index, mean arterial pressure and aortic calcification (p=0.002). Vascular inflammation was not associated with disease-related parameters.

Conclusions

Aortic vascular inflammation was significantly increased in patients with active PsA compared with controls. This evidence supports the theory that inflammation in PsA is not limited to the skin and joints but also involves the vascular system.

SUBMITTER: Kleinrensink NJ

PROVIDER: S-EPMC10836343 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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Publications

Increased vascular inflammation on PET/CT in psoriatic arthritis patients in comparison with controls.

Kleinrensink Nienke J NJ Spierings Julia J Vonkeman Harald E HE Seddiqi Negina N Herman Amin A Suijkerbuijk Karijn P M KPM Heijstek Marloes W MW Jansen Mylène P MP de Jong Pim A PA Foppen Wouter W

RMD open 20240130 1

<h4>Background</h4>Patients with psoriatic arthritis (PsA) have an increased risk of cardiovascular disease, possibly due to a chronic inflammatory state.<h4>Objectives</h4>The main objective of this study was to investigate the difference in vascular inflammation, measured with 18-fluorodeoxyglucose positron emission tomography/CT (PET/CT), in PsA patients and controls. We conducted a secondary analysis to assess the association between clinical parameters of disease activity with vascular infl ...[more]

PMID: 38296307

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Dataset Information

Increased vascular inflammation on PET/CT in psoriatic arthritis patients in comparison with controls.

Background

Objectives

Methods

Results

Conclusions

Publications

Increased vascular inflammation on PET/CT in psoriatic arthritis patients in comparison with controls.

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