UBDP1 pseudogene and UBD network competitively bind miR‑6072 to promote glioma progression.

ABSTRACT: Increasing evidence suggests that pseudogenes play crucial roles in various cancers, yet their functions and regulatory mechanisms in glioma pathogenesis remain enigmatic. In the present study, a novel pseudogene was identified, UBDP1, which is significantly upregulated in glioblastoma and positively correlated with the expression of its parent gene, UBD. Additionally, high levels of these paired genes are linked with a poor prognosis for patients. In the present study, clinical samples were collected followed by various analyses including microarray for long non‑coding RNAs, reverse transcription‑quantitative PCR, fluorescence in situ hybridization and western blotting. Cell lines were authenticated and cultured then subjected to various assays for proliferation, migration, and inv

SUBMITTER: Hong F 

PROVIDER: S-EPMC10836499 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature