Comparison of three creatinine-based equations to predict adverse outcome in a cardiovascular high-risk cohort: an investigation using the SPRINT research materials.

ABSTRACT:

Background

Novel creatinine-based equations have recently been proposed but their predictive performance for cardiovascular outcomes in participants at high cardiovascular risk in comparison to the established CKD-EPI 2009 equation is unknown.

Method

In 9361 participants from the United States included in the randomized controlled SPRINT trial, we calculated baseline estimated glomerular filtration rate (eGFR) using the CKD-EPI 2009, CKD-EPI 2021, and EKFC equations and compared their predictive value of cardiovascular events. The statistical metric used is the net reclassification improvement (NRI) presented separately for those with and those without events.

Results

During a mean follow-up of 3.1 ± 0.9 years, the primary endpoint occurred in 559 participants (6.0%).

SUBMITTER: Emrich IE 

PROVIDER: S-EPMC10836528 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature