Interaction Between Arteriosclerosis and Amyloid-β on Cognitive Function.

ABSTRACT:

Background

Dementia is a multifactorial disease, with Alzheimer's disease (AD) and vascular pathology often co-occurring in many individuals with dementia. Yet, the interplay between AD and vascular pathology in cognitive decline is largely undetermined.

Objective

The aim of the present study was to examine the joint effect of arteriosclerosis and AD pathology on cognition in the general population without dementia.

Methods

We determined the interaction between blood-based AD biomarkers and CT-defined arteriosclerosis on cognition in 2,229 dementia-free participants of the population-based Rotterdam Study (mean age: 68.9 years, 52% women) cross-sectionally.

Results

Amyloid-β (Aβ)42 and arterial calcification were associated with cognitive performance. After fur

SUBMITTER: Frentz I 

PROVIDER: S-EPMC10836547 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature