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Apolipoprotein E Polymorphisms in Andean Population of Jujuy, Argentina.


ABSTRACT: The pleiotropic nature of the apolipoprotein E (APOE) gene is associated with complex diseases in different populations. We analyzed APOE polymorphisms in 76 individuals from Jujuy - Argentina using NGS technology. The observed genotypes align with the expected Hardy-Weinberg equilibrium. APOE3 was the most common allele, followed by APOE4 and APOE2. The allele distribution pattern is consistent with findings in previously studied populations of Native Americans and Asians. The E4 allele's low frequency, always observed in a heterozygous state, raises questions regarding its relevance in explaining dementia and longevity associated with this marker in the Central Andes.

SUBMITTER: Trigo AN 

PROVIDER: S-EPMC10836601 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature

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Apolipoprotein E Polymorphisms in Andean Population of Jujuy, Argentina.

Trigo Arturo Nicolás AN   Muzzio Marina M   Figueroa Marcelo Isidro MI   Alfaro-Gómez Emma Laura EL   Bailliet Graciela G   Dopazo Hernán Javier HJ   Dipierri José Edgardo JE  

Journal of Alzheimer's disease reports 20240118 1


The pleiotropic nature of the apolipoprotein E (<i>APOE</i>) gene is associated with complex diseases in different populations. We analyzed <i>APOE</i> polymorphisms in 76 individuals from Jujuy - Argentina using NGS technology. The observed genotypes align with the expected Hardy-Weinberg equilibrium. <i>APOE3</i> was the most common allele, followed by <i>APOE4</i> and <i>APOE2</i>. The allele distribution pattern is consistent with findings in previously studied populations of Native American  ...[more]

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