The Causal Associations between Adipokines and Alzheimer's Disease: A Two-Sample Mendelian Randomization Study.

ABSTRACT:

Background

Observational studies have indicated the association of alteration of adipokines with Alzheimer's disease (AD). However, it remains unclear whether the associations are causal.

Objective

To determine the causal associations between adipokines and AD.

Methods

A Mendelian randomization (MR) method was applied to investigate the causal relationships of adipokines, including adiponectin and resistin, with risk of AD. Genetic proxies from genome-wide association studies (GWAS) of adiponectin and resistin were selected as instrumental variables. GWAS summary statistics for AD were extracted as outcome.

Results

In this study, we found evidence of the causal effects of adiponectin on AD (OR: 0.850, 95% CI: 0.731-0.990, p = 0.037). However, no relation

SUBMITTER: Cai X 

PROVIDER: S-EPMC10836602 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature