Clinical Features Associated With Rate of Fractures in Patients With Systemic Sclerosis: A US Cohort Study.

ABSTRACT:

Objective

Systemic sclerosis (SSc) is associated with several specific risk factors for fracture due to the complications of the disease and related medications. The present study was undertaken to examine the relationship between SSc-associated clinical features and fracture rate in a large US cohort.

Methods

Participants with SSc in FORWARD, The National Databank for Rheumatic Diseases, were included (1998-2019). Age- and sex-matched individuals with osteoarthritis (OA) from the same database were included as comparators. The primary end point was self-reported major osteoporotic fracture. Cox proportional hazards models were used to study the associations between risk factors and fractures.

Results

The study included 922 individuals (SSc patients, n = 154; OA patie

SUBMITTER: Rogers B 

PROVIDER: S-EPMC10836612 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature