Radiotherapy-induced vascular cognitive impairment 20 years after childhood brain tumor.

ABSTRACT:

Background

Studies have established that radiotherapy for childhood brain tumors (BTs) increases the risk of cerebrovascular disease (CVD); however, it is unclear how this will affect cognitive function. This study aimed to investigate the associations between radiotherapy-induced CVD, white matter hyperintensities (WMHs), and neurocognitive outcomes in adult survivors of childhood BTs.

Methods

In a cross-sectional setting, we conducted a national cohort that included 68 radiotherapy-treated survivors of childhood BTs after a median follow-up of 20 years. Markers of CVD and WMHs were evaluated using brain MRI, and the sum of CVD-related findings was calculated. Additionally, the associations among CVD findings, WMHs, and neuropsychological test results were analyzed.

Resu

SUBMITTER: Remes TM 

PROVIDER: S-EPMC10836776 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature