Improved early outcome prediction by MRI-based 3D tumor volume assessment in patients with CNS lymphomas.

ABSTRACT:

Background

Central nervous system lymphomas (CNSL) display remarkable clinical heterogeneity, yet accurate prediction of outcomes remains challenging. The IPCG criteria are widely used in routine practice for the assessment of treatment response. However, the value of the IPCG criteria for ultimate outcome prediction is largely unclear, mainly due to the uncertainty in delineating complete from partial responses during and after treatment.

Methods

We explored various MRI features including semi-automated 3D tumor volume measurements at different disease milestones and their association with survival in 93 CNSL patients undergoing curative-intent treatment.

Results

At diagnosis, patients with more than 3 lymphoma lesions, periventricular involvement, and high 3D tumor

SUBMITTER: Lauer EM 

PROVIDER: S-EPMC10836777 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature