Plasma Volume Oscillations during Fluid Therapy in Humans.

ABSTRACT:

Introduction

Oscillations are frequently observed on plasma dilution curves during intravenous fluid therapy. This study aimed to examine how common these oscillations are and what they represent.

Methods

Fourier transforms were used to analyze the residuals obtained during fitting of a volume kinetic model to 269 plasma dilution curves. Oscillating patterns were identified in two-thirds of the fluid infusion experiments.

Results

The wave frequency usually had a dominating frequency of 1 h or multiples thereof. The wave amplitudes varied between 1% and 4% of the plasma volume. The "peak-to-peak" amplitudes were then twice as large, which corresponded to blood volume changes of 60-240 mL. A population kinetic analysis of the distribution of infused fluid between body f

SUBMITTER: Hahn RG 

PROVIDER: S-EPMC10836926 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature