Research Progress on the Role and Mechanism of GDF15 in Body Weight Regulation.

ABSTRACT:

Background

Growth differentiation factor-15 (GDF15) is a member of the growth differentiation factor subfamily in the transforming growth factor beta superfamily. GDF15 has multiple functions and can regulate biological processes. High levels of GDF15 in the circulation can affect metabolic processes. Studies have shown that GDF15 is associated with changes in body weight.

Summary

This review reviews the current knowledge on the relationship between GDF15 and body weight change, focusing on the role and mechanism of GDF15 in body weight regulation. GDF15 plays an important role in reducing food intake, improving insulin resistance, and breaking down fat, suggesting that GDF15 has an important regulatory effect on body weight. The mechanism by which GDF15 causes reduced food

SUBMITTER: Dong XC 

PROVIDER: S-EPMC10836939 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature