Age-specific transmission dynamics of SARS-CoV-2 during the first 2 years of the pandemic.

ABSTRACT: During its first 2 years, the SARS-CoV-2 pandemic manifested as multiple waves shaped by complex interactions between variants of concern, non-pharmaceutical interventions, and the immunological landscape of the population. Understanding how the age-specific epidemiology of SARS-CoV-2 has evolved throughout the pandemic is crucial for informing policy decisions. In this article, we aimed to develop an inference-based modeling approach to reconstruct the burden of true infections and hospital admissions in children, adolescents, and adults over the seven waves of four variants (wild-type, Alpha, Delta, and Omicron BA.1) during the first 2 years of the pandemic, using the Netherlands as the motivating example. We find that reported cases are a considerable underestimate and a generally poor

SUBMITTER: Boldea O 

PROVIDER: S-EPMC10837015 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature