Acute ischemic stroke and measurement of apixaban and rivaroxaban: an observational cohort implementation study.

ABSTRACT:

Background

Treatment with intravenous thrombolysis for acute ischemic stroke is contraindicated with intake of apixaban/rivaroxaban in the last 48 hours. Recent European Stroke Organization guidelines suggest that thrombolysis can be considered if anti-factor Xa activity (AFXa) is <0.5 × 10³ IU/L with low-molecular-weight (LMWH) or unfractionated heparin (UFH) calibrated assays. Some centers also use apixaban/rivaroxaban-calibrated AFXa assays to identify patients with low drug concentrations.

Objectives

To prospectively evaluate the first year of implementation of drug-calibrated AFXa assays at our center with 2500 yearly admittances with suspected stroke.

Methods

Samples were analyzed on Sysmex CS-5100 instruments with Innovance anti-Xa reagents. Thrombol

SUBMITTER: Amundsen EK 

PROVIDER: S-EPMC10837088 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature