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Machine learning enables non-Gaussian investigation of changes to peripheral nerves related to electrical stimulation.


ABSTRACT: Electrical stimulation of the peripheral nervous system (PNS) is becoming increasingly important for the therapeutic treatment of numerous disorders. Thus, as peripheral nerves are increasingly the target of electrical stimulation, it is critical to determine how, and when, electrical stimulation results in anatomical changes in neural tissue. We introduce here a convolutional neural network and support vector machines for cell segmentation and analysis of histological samples of the sciatic nerve of rats stimulated with varying current intensities. We describe the methodologies and present results that highlight the validity of the approach: machine learning enabled highly efficient nerve measurement collection, while multivariate analysis revealed notable changes to nerves' anatomy, even when subjected to levels of stimulation thought to be safe according to the Shannon current limits.

SUBMITTER: Morales AW 

PROVIDER: S-EPMC10837107 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature

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Machine learning enables non-Gaussian investigation of changes to peripheral nerves related to electrical stimulation.

Morales Andres W AW   Du Jinze J   Warren David J DJ   Fernández-Jover Eduardo E   Martinez-Navarrete Gema G   Bouteiller Jean-Marie C JC   McCreery Douglas C DC   Lazzi Gianluca G  

Scientific reports 20240202 1


Electrical stimulation of the peripheral nervous system (PNS) is becoming increasingly important for the therapeutic treatment of numerous disorders. Thus, as peripheral nerves are increasingly the target of electrical stimulation, it is critical to determine how, and when, electrical stimulation results in anatomical changes in neural tissue. We introduce here a convolutional neural network and support vector machines for cell segmentation and analysis of histological samples of the sciatic ner  ...[more]

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