Determination of biomarker candidates for the placenta accreta spectrum by plasma proteomic analysis.

ABSTRACT: Placenta accreta spectrum (PAS) presents a significant obstetric challenge, associated with considerable maternal and fetal-neonatal morbidity and mortality. Nevertheless, it is imperative to acknowledge that a noteworthy subset of PAS cases remains undetected until the time of delivery, thereby contributing to an augmented incidence of morbidity among the affected individuals. The delayed identification of PAS not only hinders timely intervention but also exacerbates the associated health risks for both the maternal and fetal outcomes. This underscores the urgency to innovate strategies for early PAS diagnosis. In this study, we aimed to explore plasma proteins as potential diagnostic biomarkers for PAS. Integrated transcriptome and proteomic analyses were conducted to establish a novel d

SUBMITTER: Melekoglu R 

PROVIDER: S-EPMC10837117 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature