Striated preferentially expressed gene deficiency leads to mitochondrial dysfunction in developing cardiomyocytes.

ABSTRACT: A deficiency of striated preferentially expressed gene (Speg), a member of the myosin light chain kinase family, results in abnormal myofibril structure and function of immature cardiomyocytes (CMs), corresponding with a dilated cardiomyopathy, heart failure and perinatal death. Mitochondrial development plays a role in cardiomyocyte maturation. Therefore, this study investigated whether Speg deficiency ( - / - ) in CMs would result in mitochondrial abnormalities. Speg wild-type and Speg^-/- C57BL/6 littermate mice were utilized for assessment of mitochondrial structure by transmission electron and confocal microscopies. Speg was expressed in the first and second heart fields at embryonic (E) day 7.5, prior to the expression of mitochondrial Na⁺/Ca2⁺/Li

SUBMITTER: Li G 

PROVIDER: S-EPMC10837246 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature