Is source-resolved magnetoencephalographic mismatch negativity a viable biomarker for early psychosis?

ABSTRACT: Mismatch negativity (MMN) is an auditory event-related response reflecting the pre-attentive detection of novel stimuli and is a biomarker of cortical dysfunction in schizophrenia (SZ). MMN to pitch (pMMN) and to duration (dMMN) deviant stimuli are impaired in chronic SZ, but it is less clear if MMN is reduced in first-episode SZ, with inconsistent findings in scalp-level EEG studies. Here, we investigated the neural generators of pMMN and dMMN with MEG recordings in 26 first-episode schizophrenia spectrum (FE_sz) and 26 matched healthy controls (C). We projected MEG inverse solutions into precise functionally meaningful auditory cortex areas. MEG-derived MMN sources were in bilateral primary auditory cortex (A1) and belt areas. In A1, pMMN FE_sz reduction showed a tren

SUBMITTER: Lopez-Caballero F 

PROVIDER: S-EPMC10837325 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature