Systemic immune-inflammation index predicts first stroke and affects the efficacy of folic acid in stroke prevention.

ABSTRACT:

Background

Systemic immune-inflammation index (SII) is a novel biomarker of growing interest in predicting stroke. The aim of this study was to investigate its predictive value and explore its effect modification on folic acid supplement for stroke primary prevention in a Chinese population with hypertension.

Methods

A total of 10,013 participants from the China Stroke Primary Prevention Trial with available neutrophil, platelet and lymphocyte count were included, including 5,019 subjects in the enalapril group and 4,994 in the enalapril-folic acid group. SII was calculated as (platelet × neutrophil)/lymphocyte. The primary endpoint was first stroke. Cox proportional hazards models were used to evaluate the association between SII and first stroke.

Results

A U-shape a

SUBMITTER: Chi X 

PROVIDER: S-EPMC10837552 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature