Blood and Imaging Biomarkers in the Long-term Follow-up of Bicuspid Aortic Valve Patients.

ABSTRACT:

Background

Bicuspid aortic valve (BAV) is a common congenital heart defect. Patients with BAV are at risk for long-term complications such as valve stenosis and regurgitation. This study aimed to investigate sex differences in blood and imaging biomarkers and to describe the long-term prognostic value of blood and echocardiographic biomarkers.

Methods

Patients were included from 2 prospective observational cohort studies; they underwent venous blood sampling and transthoracic echocardiography including speckle tracking. Analyzed blood biomarkers were red-cell distribution width (RDW), creatinine, C-reactive protein (CRP), troponin T, N-terminal pro B-type natriuretic peptide (NT-proBNP), and transforming growth factor-beta (TGF-β). Sex differences were analyzed at baseline.

SUBMITTER: Keuning ZA 

PROVIDER: S-EPMC10837668 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature