Efficacy of H₂O₂ inactivated bovine virus diarrhoea virus (BVDV) type 1 vaccine in mice.

ABSTRACT:

Background

Bovine viral diarrhea (BVD) is an acute febrile infectious disease caused by the bovine viral diarrhea virus (BVDV), which has brought huge economic losses to the world's cattle industry. At present, commercial inactivated BVDV vaccines may cause some adverse reactions during use. This study aims to develop a safer and more efficient inactivated BVDV vaccine.

Methods

Here, we described the generation and preclinical efficacy of a hydrogen peroxide (H₂O₂) inactivated BVDV type 1 vaccine in mice, and administered it separately with commercial vaccine (formaldehyde inactivated) in mice to study its efficacy.

Results

The BVDV type 1 IgG, IFN- γ, IL-4 and neutralizing antibody in the serum of the H₂O₂ inactivated vacci

SUBMITTER: Li C 

PROVIDER: S-EPMC10837870 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature