Association of single nucleotide polymorphisms in the F2RL1 gene with clinical and inflammatory characteristics of patients with asthma.

ABSTRACT:

Background

Proteinase-activated receptor 2 (PAR-2) is a G-protein coupled receptor associated with many inflammatory diseases, including asthma. We have shown an association between PAR-2 expression in peripheral blood monocytes and asthma severity as well as blood PAR-2 mRNA level and lung function. Since F2RL1 (the gene encoding PAR-2) polymorphisms affect PAR-2 expression, we hypothesize they may affect asthma severity.

Methods

We recruited 76 subjects with asthma of varying severity and collected clinical (FEV₁ [% predicted], FEV₁/FVC, IgE) and immunological (PAR-2 mRNA, blood eosinophils) disease parameters. We also genotyped these individuals for 3 F2RL1 SNPs (-45C/T, -149C/G, c.621C/T).

Results

We found that the F2RL1 SNP "C" allele of -45

SUBMITTER: Shrestha Palikhe N 

PROVIDER: S-EPMC10837890 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature