A multicenter double-blind randomized crossover study comparing the impact of dorsal subthalamic nucleus deep brain stimulation versus standard care on apathy in Parkinson's disease: a study protocol.

ABSTRACT:

Background

Neuroimaging studies suggest an association between apathy after deep brain stimulation (DBS) and stimulation of the ventral part of the subthalamic nucleus (STN) due to the associative fibers connected to the non-motor limbic circuits that are involved in emotion regulation and motivation. We have previously described three patients with severe apathy that could be fully treated after switching stimulation from a ventral electrode contact point to a more dorsal contact point.

Objectives

To determine whether more dorsal stimulation of the STN decreases apathy compared to standard care in a multicenter randomized controlled trial with a crossover design.

Methods

We will include 26 patients with a Starkstein Apathy Scale (SAS) score of 14 or more after subtha

SUBMITTER: Zoon TJC 

PROVIDER: S-EPMC10837902 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature