Identification and analysis of key circRNAs in the mouse embryonic ovary provides insight into primordial follicle development.

ABSTRACT:

Background

CircRNAs are a class of noncoding RNAs with tissue- and development-specific expression characteristics. In many mammals, primordial follicle development begins in the embryonic stage. However, the study of circRNAs in primordial follicle development in mice has not been reported.

Results

In this study, ovaries were collected from mouse foetuses at 15.5 days post coitus (dpc) and 17.5 dpc, which are two key stages of primordial follicle development. A total of 4785 circRNAs were obtained by using RNA-seq. Of these, 83 differentially expressed circRNAs were identified. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses showed that these differential circRNAs were mainly involved in the regulation of reproductive development. T

SUBMITTER: Wang X 

PROVIDER: S-EPMC10837906 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature