The effect of haloperidol's perioperative application on postoperative delirium in elderly patients: a systematic review and meta-analysis.

ABSTRACT:

Objectives

To systematically review the evidence about the effect of haloperidol on postoperative delirium in elderly patients.

Methods

PubMed, Embase, the Cochrane Library and China National Knowledge Infrastructure were used to find concerned studies for meta-analysis. The main outcome was the incidence of postoperative delirium, and the secondary outcomes were side effects of haloperidol and the length of hospital stay. The meta-analyses were conducted using the Review Manager Version 5.1. This study was conducted based on the PRISMA statement.

Results

Eight RCTs (1569 patients) were included in the meta-analysis. There was a significant difference in the incidence of postoperative delirium between haloperidol and control groups (OR = 0.62, 95%CI 0.48-0.80, P = 0.0

SUBMITTER: Liu M 

PROVIDER: S-EPMC10837937 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature